SOURCE: The JAMA Network Journals
A “healthy lifestyle pattern” was defined as never or past smoking; no or moderate drinking of alcohol (one or less drink a day for women, two or less drinks a day for men); BMI of at least 18.5 but lower than 27.5; and weekly aerobic physical activity of at least 150 minutes moderate intensity or 75 minutes vigorous intensity. Individuals who met all four criteria were considered low risk and everyone else was high risk.
The study included 89,571 women and 46,399 men; 16,531 women and 11,731 had a healthy lifestyle pattern (low-risk group) and the remaining 73,040 women and 34,608 men were high risk.
The authors calculated population-attributable risk (PAR), which can be interpreted as the proportion of cases that would not occur if all the individuals adopted the healthy lifestyle pattern of the low-risk group.
The authors suggest about 20 percent to 40 percent of cancer cases and about half of cancer deaths could potentially be prevented through modifications to adopt the healthy lifestyle pattern of the low-risk group.
The authors note that including only white individuals in their PAR estimates may not be generalizable to other ethnic groups but the factors they considered have been established as risk factors in diverse ethnic groups too.
“These findings reinforce the predominate importance of lifestyle factors in determining cancer risk. Therefore, primary prevention should remain a priority for cancer control,” the authors conclude.
- Mingyang Song, MD, ScD, Edward Giovannucci, MD, ScD. Preventable Incidence and Mortality of Carcinoma Associated With Lifestyle Factors Among White Adults in the United States. JAMA Oncol., May 2016 DOI: 10.1001/jamaoncol.2016.0843
- Graham A. Colditz, MD, DrPH; Siobhan Sutcliffe, PhD. The Preventability of Cancer: Stacking the Deck. JAMA Oncol, May 2016 DOI: 10.1001/jamaoncol.2016.0889